Platelet Rich Plasma (PRP) was a first generation platelet concentrate that gained popularity because it could concentrate regenerative cells and growth factors with a simple blood draw that dramatically promoted tissue healing. Despite its popularity in facial esthetics, medicine and dentistry, one of the consistently reported drawbacks was the use of anticoagulants (often derived from animal sources). This was proven to limit the natural regenerative process by preventing clotting (or coagulation).
By removing these anticoagulants, changing the technology and spin protocols, and modifying the blood-collection tubes, it has since been possible to further extend the natural growth factor delivery in a 100% natural manner with no chemical additives. PRF has since been defined as a 2nd generation platelet concentrate with data demonstrating up to 3 times more positive effects on cellular bioactivity when compared to traditional PRP. Bio-PRF is an upgraded centrifugation system with protocols that even further improve the regenerative potential of PRF up to 10x.
PRF Platelet Rich Fibrin